I take 3 in the morning and 3 at night. I don't want to decrease my dose cause if I miss a dose I feel like crap (this term is used loosely; 'crap' to me now would be a 'vibrant' day before the MD!)a few hours after. I guess lowering it by one pill a day wouldn't be as drastic as missing 3...We'll see.
I've heard over and over that liver and Colon Cleanses clear up your skin beautifully....
BUT you aren't supposed to do those while you're on the Primal Defense detox because they wipe out the colonies of good bacteria that the Primal Defense is trying to establish in your gut.
Let us know if you find anything more out or after you do the cleanse!