The Maker's Diet is designed to work with the Garden of Life products as a 'stand alone' cleansing/detox program.
I have been on Primal Defense for four months now and have never felt better or more in tune with my body in my life. I will never go off the MD and expect to live a wonderfully healthy. long, disease-free life because of it. (I'm only 22)
I've also been on the Maker's Diet for a few months.
If you take the right supplements for you (EVERY GoL product I've tried I've noticed such a change that I won't give them up!) and follow the diet and listen to your body, I believe wholeheartedly you will get and stay detoxed. :)