hi, kj. I'm so glad you responded to my post. Can you tell me about how you discovered you have Protien S deficiency? And what is cryofibrinogenemia? Did you have problem pregnancies? Are you young? I sure would like to find more from others who have the problem and how it affects them. My daughter is experiencing a tightness in her arms and legs. She had toxemia with her 3 pregnancies. She had one child who is now 8 years old, who was born 1lb. 1oz. Second baby was 1lb. 10oz. and he died after 4 days. Third baby was 4lbs. She is now 4 years old. All of the babies were born early because of toxemia, which is somehow connected to Protien S and Protien C deficiency. Please tell me your story.