There are several vitamins and minerals required to produce D6D, the enzyme the body uses to transform both omega 6 and omega 3 fatty acids into substances that benefit the body. If you are low in any one of these nutrients it can greatly affect the breakdown and assimilation of both omegas. And since both types of omegas are polyunsaturated they go rancid in the body very fast. So delays in their processing can cause them both to become inflammatory substances. Both can follow a pathway to produce helpful prostaglandins, but if they they are not reduced to that point there can be problems. Also, both omegas compete for that often rare D6D, so if you aren't making much from the start, it can cause some of both to go rancid, which might explain your inflammatory reaction if you consume both together. I'm like you in that I tend to need more w6 than w3 because I eat plenty of wild caught fish, and I cook with coconut oils. My overall consumption of w6's is pretty low most days, and has been for nearly a year. Fortunately, I can still eat w3's but I have to supplement w6's. I believe I have finally replenished my nutrients enough to produce near adequate levels of D6D, but now I need to get my ratios in balance.