receptor sites are created by the cell and their number can be adjusted based on perceived need. Receptor sites are transient in nature. They are not intended to be permanent, they bind with with the chemical messenger, carry out their task and are replaced. So when I said game over I simply meant that specific receptor was "used up". In the case where a ligand is bound but the receptor is not activated the receptor is often not readily replaced and thereby the overall effectiveness of the cell is muted because it number of available receptors is reduced.
This is why the toxic halides are so destructive, not only does their existence reduce the odds of an iodine based ligand to trigger the needed chemical reaction but they occupy receptors without triggering a response.
Its like having 2 grocery stores across the street from each other. Half of the parking lot for store A is filled by cars that walked across the street and shopped at store B. By them parking in store A's lot they greatly reduce the number of shoppers that can park in their lot.
Needless to say the above is a gross over simplification.