Most natural vitamins are far better. Vitamin C is the big exception for the body accepts and uses it the same as natural ascorbic acid. Natural vitamin C is slightly better but cost is more than I can afford. I have used chemical version for over fifty years with no adverse affects. Natural medicine doctors use from five to 200 grams a day oral, injection and IV, to cure all sorts of ailments. Research Dr Klenner, Dr levy, Andrew Saul and whole slew of others. see ‘doctoryourself.com'