Thank you for replying to my message. I pray you are dong well. There are some days that I only take my supplements 2x a day but I mostly take all of them 3x a day. I have not noticed a difference if I only take the 2x vs 3x. I will have to pay closer attention to that. I've heard people say that the Endodren makes them jumpy and jittery. Not so with me. I haven't found a supplement that makes me jumpy or gives me too much energy. That would definitely surprise me.