Re: Candida Diets: Part III: Bacillus Subtilis

Here are some sources below. Many people approach eliminating candida as though it existed in a test tube, with little regard for the rest of the cells of the body, including the necessary bacterial cells. Creating other imbalances in the body can result in long-term problems. This forum and the Candida Support forum are filled with examples of Threelac, Syntol, and other Bacillus subtilis containing products not working at all, or just for a short period of time. Preserving the internal environment while correcting for imbalances is very important. Dumping fungal substances into the body by killing candida activates a strong inflammatory state that create other imbalances. It will always be about creating balance. The medical approach is all about killing off bacteria, fungus, etc. The holistic approach never should be.

B. subtilis
As already explained, early records of infection
ascribed to B. subtilis often used that name as a
synonym for “aerobic sporeforming bacilli”. Since
1970, however, there have been several reports of
B. subtilis infection in which the identification of
the species appears to have been reliable. Cases
described include ; endocarditis after drug abuse
(cleared by cephalosporin therapy) ; fatal pneumonia
and bacteraemia in three leukaemic patients
(in two of whom the B. subtilis isolates were
regarded as contaminants but were subsequently
cultured from lung infarcts at necropsy ; Pennington
et al., 1976) ; septicaemia (cleared by gentamicin
therapy) in a patient with metastasising carcinoma
of the breast; infection of a necrotic axillary tumour
in another breast-cancer patient ; and isolations
from a pleural effusion contiguous to a subphrenic
abscess, from a breast prosthesis, from several
surgical wound-drainage sites (Ihde and Armstrong,
1973) and from two ventriculo-atrial shunt
infections, one of which was associated with
bacteraemia (Tuazon et al., 1979). Furthermore,
the use in laundry products of B. subtilis derivatives
containing proteolytic enzymes has resulted in cases
of dermatitis and respiratory ailments (see Norris
et al., 198 1).
Several episodes of food poisoning have been
attributed to B. subtilis; it has often been found in
almost pure culture in large numbers (> lo6 cfu/g)
in the implicated foods which were usually meat
dishes such as sausage rolls, meat pasties and stuffed
poultry but also included pizza and wholemeal
bread. Symptoms of vomiting, with diarrhoea in
more than half of the incidents, occurred after
incubation periods ranging from 15 min to 10 h
(Gilbert et al., 1981 ; Kramer et al., 1982).
http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=8&ved=0CGwQFjAH&...


The transfer of gene sequences between strains of B. subtilis has been demonstrated when the strains were grown together in soil (Graham and Istock, 1979). In addition, Klier et al. (1983) demonstrated the ability of B. subtilis and B. thuringiensis to exchange high frequency transfer plasmids. Other studies have shown that B. subtilis has the ability to express and secrete toxins or components of the toxins that were acquired from other microorganisms through such transfers of genetic material. B. subtilis expressed subunits of toxins from Bordatella pertussis (Saris et al., 1990a, 1990b), as well as subunits of diphtheria toxin (Hemila et al., 1989) and pneumolysin A pneumococcal toxin (Taira et al., 1989). Although B. subtilis does not appear to possess indigenous virulence factor genes, it is theoretically possible that it may acquire such genes from other bacteria, particularly from closely related bacteria within the genus.
A review of the literature by Edberg (1991) failed to reveal the production of toxins by B. subtilis. Although it has been associated with outbreaks of food poisoning (Gilbert et al., 1981 and Kramer et al., 1982 as cited by Logan, 1988), the exact nature of its involvement has not been established. B. subtilis, like other closely related species in the genus, B. licheniformis, B. pumulis, and B. megaterium, have been shown to be capable of producing lecithinase, an enzyme which disrupts membranes of mammalian cells. However, there has not been any correlation between lecithinase production and human disease in B. subtilis.
B. subtilis does produce an extracellular toxin known as subtilisin. Although subtilisin has very low toxigenic properties (Gill, 1982), this proteinaceous compound is capable of causing allergic reactions in individuals who are repeatedly exposed to it (Edberg, 1991). Sensitization of workers to subtilisin may be a problem in fermentation facilities where exposure to high concentration of this compound may occur. Exposure limits to subtilisin are regulated by Occupational Safety and Health Administration (OSHA) (29 CFR 1900, et seq.)
B. subtilis appears to have a low degree of virulence to humans. It does not produce significant quantities of extracellular enzymes or possess other virulence factors that would predispose it to cause infection (Edberg, 1991). There are a number of reports where B. subtilis has been isolated from human infections. Earlier literature contains references to infections caused by B. subtilis. However, as previously stated,the term B. subtilis was synonymous for any aerobic sporeforming bacilli, and quite possibly, many of these infections were associated with B. cereus. In a recent British review article, Logan (1988) cites more recent cases of B. subtilis infections in which identification of the bacterium appeared reliable. Infections include a case of endocarditis in a drug abuse patient; fatal pneumonia and bacteremia in three leukemic patients; septicemia in a patient with breast cancer; and infection of a necrotic axillary tumor in another breast cancer patient. Isolation of B. subtilis was also made from surgical wound-drainage sites, from a subphrenic abscess from a breast prosthesis, and from two ventriculo-atrial shunt infections (as cited by Logan, 1988).
Reviews of Bacillus infections from several major hospitals suggest that B. subtilis is an organism with low virulence. Idhe and Armstrong (1973) reported that Bacillus infections were encountered only twelve times over a 6-1/2 year period. Species identification of these Bacillus infections was not made. In another hospital study over a 6-yr. period, only two of the 24 cases of bacteremia caused by Bacillus (of a total of 1,038 cases) were due to B. subtilis (as cited by Edberg, 1991). Many of these patients were immunocompromised or had long term indwelling foreign bodies such as a Hickman catheter.
B. subtilis has also been implicated in several cases of food poisoning (Gilbert et al., 1981 and Kramer et al., 1982 as cited by Logan, 1988).
As previously mentioned, B. subtilis produces a number of enzymes, including subtilisin, for use in laundry detergent products. There have been a number of cases of allergic or hypersensitivity reactions, including dermatitis and respiratory distress after the use of these laundry products (Norris et al., 1981).
B. subtilis has been shown to produce a wide variety of antibacterial and antifungal compounds (Katz and Demain, 1977; Korzybski et al., 1978). It produces novel antibiotics such as difficidin and oxydifficidin that have activity against a wide spectrum of aerobic and anaerobic bacteria (Zimmerman et al., 1987) as well as more common antibiotics such as bacitracin, bacillin, and bacillomycin B (Parry et al., 1983). The use of B. subtilis as a biocontrol agent of fungal plant pathogens is being investigated because of the effects of antifungal compounds on Monilinia fructicola (McKeen et al., 1986), Aspergillus flavus and A. parasiticus (Kimura and Hirano, 1988), and Rhizoctonia (Loeffler et al., 1986).
http://epa.gov/biotech_rule/pubs/fra/fra009.htm


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