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Re: Copper Toxicity and dark ring around iris
 

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ways_of_wisdom Views: 27,042
Published: 13 y
 
This is a reply to # 1,975,660

Re: Copper Toxicity and dark ring around iris


Yes, you are right, the term used in the show was "poisoning" and the ring around the iris was very pronounced, mine is thin but it's there.

Apparently you didn't read the Wikipedia page, so I'm pasting a paragraph here: 

Kayser-Fleischer rings are a sign of Wilson's disease, which involves abnormal copper handling by the liver resulting in copper accumulation in the body and is characterised by abnormalities of the basal ganglia of the brain, liver cirrhosis, splenomegaly, involuntary movements, muscle rigidity, psychiatric disturbances, dystonia and dysphagia. The combination of neurological symptoms, a low blood ceruloplasmin level and KF rings is diagnostic of Wilson's disease.[1]

While they're probably referring to a more advanced stage, notice that the one thing in common is that the liver is affected, and I've always seen liver disfunction associated with hypoglycemia and/or AF.  But I just noticed something else, which is what I originally thought I was told about my "rings":

Other causes of KF rings are cholestasis (obstruction of the bile ducts), primary biliary cirrhosis and "cryptogenic" cirrhosis (cirrhosis in which no cause can be identified).[1]

In any case, I'm sure there are different stages of copper "overload".  And btw, in the TV show, which I know must not be taken as "truth", when the patient asked how that had happened to her the doc said there was no good way to know, that she'd probably had  been accumulating it most of her life.  From what I've read so far, it's actually the liver's inability to produce sufficient ceruloplasmin in the first place which causes the copper build-up, and of course, like some other conditions the cause also facilitates the progression of the disease by producing a vicious circle of sorts.

 

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