Re: debate

Quote: Many studies regarding myocardial ischemia and reperfusion show that leukotriene signaling may be involved in the development of ischemic injury.

They are probably wrong about the "development" part. Leukotrienes are most likely the response to atherosclerotic injury rather than the cause of it. If leukotrienes are not the cause then AA isn't either. See this study: Leukotriene receptors in atherosclerosis .

Quote:

Leukotriene-forming enzymes are expressed within atherosclerotic lesions and locally produced leukotrienes exert pro-inflammatory actions within the vascular wall by means of cell surface receptors of the BLT and CysLT receptor subtypes. ...

Notice that the authors hedge their bets both ways and also stipulate the causative role as well, although I doubt that this is right. I think it is much more plausible that the inflammation associated with atherosclerotic lesions an re-stenosis is the reaction to injury not the cause of it. Many cardiologists (though not all) would probably agree Tweet