Re: debate

[cont>

Dietary arachidonic acid and inflammation.

Under normal metabolic conditions, the increased consumption of arachidonic acid is unlikely to increase inflammation[citation needed >. ARA is metabolized to both pro-inflammatory and anti-inflammatory molecules[17> . Studies giving between 840 mg and 2,000 mg per day to healthy individuals for up to 50 days have shown no increases in inflammation or related metabolic activities[18> [17> [19> [20> .



Increased arachidonic acid levels are actually associated with reduced pro-inflammatory IL-6 and IL-1 levels, and increased anti-inflammatory tumor-necrosis factor-beta[21> . This may reduce inflammation under certain conditions.


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Health effects of arachidonic acid supplementation

Arachidonic acid supplementation in daily dosages of 1,000-1,500 mg for 50 days has been well tolerated during several clinical studies, with no significant side effects reported. All common markers of health including kidney and liver function[19> , serum lipids[23> , immunity[24> , and platelet aggregation[18> appear to be unaffected with this level and duration of use. Furthermore, higher concentrations of ARA in muscle tissue may be correlated with improved insulin sensitivity[25> .
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