Re: More on Sulfation, liver pathway

I can't find in the book where Cutler talks about Carnosine--maybe it's not in the index. Do you have more information on the dosages, and frequency?

It snowed here again today, good day to be in studying.

But, I've also been trying to figure something out.

I don't know where I thought I was reading about the Sulfation (PST enzyme)processing the dopamine,&seratonin--because that's not what the Phase 2 pathways info in Cutler's book shows.

Pg 51 in Cutler's book:

The catecholamine transmitter pathway is pheylalanine--->tyrosine --->dopamine--->norepinephrine--->epinephrine is the metabolic pathway to make neurotransmitters from the amino acids phenylalaninie and tyrosine. The conversion of norepinephrine to epinephrine requires methylation.

(as I've heard you say before, broken methylation)

I had a friend send me the results of tests he's had done--urine showed high dopamine,& high norepinephrine- which I'm seeing in Cutler's book on page 42 are both in the Methylation pathway.

But why would they be high? Mercury interfering with the pathways, plus inhibiting the effects of the transmitters? So instead of being deficient, it's accumulating?

This?
http://www.drkaslow.com/html/mercury_s_influence.html


>>>Brain and Learning: Birth defects involving the brain and learning ability, can be caused by mercury, as the metal can passes through both the placental barrier into the fetus and the blood-brain barrier. There is a sheep study documenting that the fetus actually accumulates and concentrates mercury from the mother!

Accumulation in the brain leads to mental and nervous system effects such as brain fog, depression, vision difficulties, and others as listed above. Mental effects are among the most common due to mercury's strong affinity for the brain. Mercury inhibits the effects of certain neurotransmitters:

Dopamine: controls pain, well-being
Serotonin: relaxation, sleep, well-being
Adrenaline: energy and stamina
Noradrenaline, melatonin: sleep cycles
Inhibition of these neurotransmitters by mercury can account in part for the feelings of Depression and loss of motivation.>>>>

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Cortisol was also high, and I am seeing that it is in the Sulfation pathway, as is thyroxine (thyroid). His Iodine was low.

From Wiki:
>>>The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. An important component in the synthesis of thyroid hormones is iodine.>>
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Lithium was low (from the same link as above):

>>>>Mercurous ion (Hg+1) pushes out Na+1 (sodium), K+1 (potassium), and Li+1 (lithium). Sodium and potassium are part of the cellular sodium/potassium pump which causes muscle movement. Interference with sodium and potassium can lead to muscle weakness for this reason. Leg and muscle cramps may be due to potassium deficiency.

Lithium is sometimes given as lithium carbonate to patients suffering from bipolar Depression (manic depressive illness) since lack of lithium is one of the causes of the disease. Lack of lithium may itself be caused by mercury preventing lithium from working as it should in the brain. Mercury is like the 200 pound bully attacking a 7 pound baby; the small baby doesn't have much of a chance. 200 and 7 are the molecular weights of mercury (the bully) and lithium (the baby) respectively. If you have been diagnosed with bipolar depression, maybe what you need is less mercury, not more lithium pills.




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