Re: More on Sulfation, liver pathway

part 3:

MSM works with copper in many functions, and may get depleted with
copper supplementation or when high copper levels are present.
Additionally, our soils are depleted of sulfur, and such sulfonyl as
there is in foods is lost in cooking. MSM is a white, crystalline
powder that is odorless and somewhat bitter tasting. It mixes in
water more easily than sugar, and just barely affects the taste. In
juice or other beverages, it is undetectable. MSM is effective in
ameliorating gastrointestinal upsets such as that produced by the
ingestion of aspirin and other pharmaceuticals, or that from
parasitic infections. Individuals with gastrointestinal symptoms such
as diarrhea, chronic constipation, nausea, hyperacidity and/or
epigastric pain (having been reported more effective than Tagamet™),
or inflammation of mucous membranes also will experience dramatic
relief. Individuals presenting symptoms of pain and inflammation
associated with various musculoskeletal system disorders, including
arthritis, report substantial and long-lasting relief. Those lacking
in sulfite oxidase cannot metabolize MSM, or the sulfite used in
Chinese foods or on some green salads, to sulfate, and may get
headache, dizziness, fatigue, wheezing, leg pain, and other symptoms.
MSM also seems to cause hair loss when there is heavy metals
poisoning, particularly mercury. This may be overcome by
supplementing molybdenum and vitamin B6, and this will enable more
efficient metabolism in this pathway relieving the sensitivity to
sulfur-bearing foods, and producing needed sulfates. Many cannot
tolerate more than 500 mg MSM, yet show very positive benefits from
even this amount. So, start low and increase dosage as you can
tolerate it. Always supplement molybdenum when taking MSM. Two
hundred to 300 mcg a day may be enough, but moly absorbs poorly, and
adults may require 1000 mcg twice daily for three or four months or
longer to overcome this aversion to sulfur-bearing foods.

One should note that mercury binds to the -SH (sulphydryl) groups,
resulting in inactivation of sulfur and blocking of enzyme function,
producing toxicity. Sulfur is essential in enzymes, hormones, nerve
tissue, and red blood cells. Mercury also blocks the metabolic action
of manganese and the entry of calcium ions into cytoplasm. Mercury
thus has the potential to disturb all metabolic processes. Under
these conditions MSM should be most helpful.

DMSO is being used as the solvent in transdermal secretin. This is
essentially the same as MSM. At least one Mom is reported to have
found good results with DMSO alone. When she added secretin further
gains were noted, but when she ran out of secretin, the gains
continued with DMSO alone! DMSO has long had a reputation as a
panacea for about everything that ails you. A case in point, applying
it to the abdomen has alleviated all symptoms of colitis and
Irritable Bowel Syndrome. Both it and MSM work wonders for arthritis.
To avoid skin dryness, dilute it 15% with distilled water.

If the child can metabolize organic sulfur (like MSM/DMSO) all the
way to sulfate, then MSM is a good way of increasing sulfate.
However, if the enzyme sulfite oxidase is not working well, then MSM
is a bad idea. Sulfite oxidase requires molybdenum as a cofactor, and
since mercury depletes selenium; and mercury, MSM, oral sulfate, and
copper tends to deplete molybdenum, selenium and molybdenum must be
supplemented. Conversely, tungsten inhibits the action of molybdenum
and thus of the molybdenum-based enzymes sulfite oxidase, xanthine
oxidase, and aldehyde oxidase. This would likely cause an excess of
molybdenum to accumulate. Thus, both excess mercury and excess
tungsten would create a shortage of the listed enzymes.

A coenzyme, vitamin B-complex supplement of moderate potency should
be supplemented. One mother in supplementing molybdenum reports that
her daughter, who was doing quite well, regressed into severe,
autistic symptoms for three days, including 18 hours of screaming-
possibly due to detoxifying. Her doctor urged her to cease, but she
stayed the course, and today her daughter is far and away better!
This is serious stuff.

Incidentally, a gross deficiency of molybdenum manifests as
tachycardia, headache, mental disturbances, and coma. An excess
intake of 10-15 mg daily (for adults) can cause a gout like syndrome
because of an elevated production of uric acid. Dosage range should
not exceed 1 mg per day (adult), bearing in mind that more than 0.5
mg causes a loss of copper. Very little molybdenum is needed, but it
is an important element in several important metalloenzymes (xanthine
oxidase, aldehyde oxidase, and sulfite oxidase) that participate in
crucial liver detoxification pathways.

Until the body regains its ability to oxidize sulfur, it may be
desirable to limit high sulfur containing foods (cruciferous
vegetables, broccoli, onions, garlic, turnips, eggs, red meat,
turkey, dairy products); and supplements like alpha lipoic acid,
glutathione, L-cysteine, and N-acetylcysteine (NAC can be better
tolerated when used with its team mates, the amino acids glycine and
glutamine in ratio 2:1:1, and the B-complex vitamins. It should be
tried for the glutathione it produces is so vital). Those who have a
problem with these foods likely have an impaired sulfur oxidation (a
cysteine oxidation) problem, and should be alert to cysteine
toxicity. Even those who do not oxidize cysteine well can usually
tolerate NAC at 500 mg daily (adult dose) without contributing to
cysteine toxicity. Supplying any of these sulfur foods may be a
problem to some of these kids who do not oxidize sulfur well. One
indicator may be fatigue after eating these. Unless a problem is
observed, however, these foods should not be restricted unnecessarily
for that will cause a reduction of the vital antioxidant glutathione,
and interfere with the conversion of T4 thyroid hormone into T3.

Blueberry extract, grape seed extract, pine tree bark, Resveratrol,
green tea, and other things have phenols, salicylates, and other
stuff that are normally detoxified by PST.

Some recent studies indicate that salicylate has an effect on PST, an
enzyme needed by the brain and the gut to metabolize high-phenolic
compounds like the artificial colors and flavors. Salicylate
suppresses PST enzymes up to 50%. Phase II has been shown to be low
for people with ADHD or autism. Excess boron interferes with the
metabolism (breakdown and excretion) of phenols. Ritalin, used in the
treatment of ADHD, inhibits the metabolism of coumarins (phenols).
Supplementing boron reduces calcium losses by 30%, but excess boron
increases copper in the body. High copper levels reduce the vitamin
B1, and this reduces oxygen supply to the brain. Excess boron reduces
the vitamin B6 levels in the body also. Boron is found in apples,
pears, grapes, nuts, leafy green vegetables, and legumes. Supplying
these substances, especially apples, pears, and grapes, or their
juices in large amounts to PST deficient children, will cause a build
up of phenols, amines, salicylates, and other toxic substances
normally cleared by PST.

In fact, any chemicals with a high proportion of phenolic groupings
will have this effect, and will enhance the problems referred to
above. Methyl Salicylate: (Salicylic Acid, Wintergreen Oil) is one
such. This phenolic is toxic in moderate concentrations. It is used
in birch beer, chewing gum (in high concentrations), grape, mint,
root beer, sarsaparilla, spice, walnut and wintergreen flavor in
baked goods, beverages, candy, ice cream, ices, syrups, mint-scented
cleaning products, and in perfumery. Symptoms of methyl salicylate
poisoning are acidosis, pulmonary edema and vomiting. This compound
has lethal drug interactions with many substances including
anticoagulants, tricyclic antidepressants, indocin, and methotrexate.
Gallic Acid is another. Gallic Acid is found in food coloring agents
and is, unquestionably, the most important of all phenolics.
Neutralization of gallic acid is the basis of the Feingold Diet,
which eliminates salicylates.

Beef patties containing 30% fat and grilled over mesquite wood had 24
aromatics at a total concentration of 549 g/kg of meat while the same
beef cooked over hardwood (hickory) charcoal had 16 aromatics
representing 68 g/kg. A heavy smoke flavor would produce a higher
concentration of phenols than light smoke. Hamburgers barbecued with
lots of smoke (especially in a covered grill) may be a potential
phenol problem as well as smoked bacon. Smoked bacon cured with
nitrates is even more toxic than phenols by themselves.

Additionally, fruit sugars will feed the candida causing an explosive
overgrowth with increased acetylaldehyde toxins. Candida also
produces arabinose and tartaric acid. Dr. Wm. Shaw of The Great
Plains Laboratory, Inc. thinks that high concentrations of arabinose
may inhibit the liver's production of glucose, causing hypoglycemia
and impairing neurological function. Cheney described two boys
diagnosed as autistic. Their urine test showed high levels of
arabinose and tartaric acid. Tartaric acid looks like malic acid, and
poisons cells by interfering with the Krebs Cycle. Both boys had been
on repeated Antibiotics for recurring ear infections, and had not
been autistic until recently. They were about six years old. In these
unusual cases, when the boys were treated with Nystatin™, they both
recovered, and were no longer autistic!

Many coloring materials (porphyrin), whether of natural or synthetic
origin, possess phenolic groupings. For this reason, some
practitioners recommend the removal of all pigmented foods from the
diet (Sara's Diet). This may not be necessary due to the nature of
enzyme activity (the greater the need, the faster it works), but you
must at least eliminate juices (or limit to a little pear juice), and
eliminate all artificial colors and flavors. Avoid "deodorant" soaps
and deodorants containing "triclosan," a chlorophenol. It should be
noted that problems relating to inhibition of cytochrome p450 liver
enzymes (Phase I liver detoxing) are involved with porphyrin in the
foods and supplements named in the above paragraphs. Additionally,
potatoes, tomatoes, and egg plant contain glycoalkaloids, that, even
in small amounts, can greatly slow the metabolism of anesthetic
agents and muscle relaxants, requiring up to 10 times longer to
recover from an anesthetic.

DPT immunization in inbred mice has been shown to result in decreased
synthesis of cytochrome p450, and of phosphosulfotransferase, and of
the messenger RNA necessary for their production. A decrease in
production of the liver enzymes phosphosulfotransferase and the
cytochrome p450 family of enzymes causes failure to break down food
proteins (including gluten and casein) into amino acids. The
resulting intermediates, called peptides, can cross into the blood.
Anything that further inhibits these cytochrome p450 liver enzymes
would compound the problem of toxicity, and further contribute to the
opioid problem. "Treatment of the latter (candida) with conventional
synthetic antifungal agents often causes impairment of liver
detoxification functions, and a decrease in the synthesis of
phosphosulfotransferase, an enzyme necessary to cleave food proteins,
e.g. casein, into smaller easily absorbable peptides."-Dr. Hugh
Fudenberg, MD. Many drugs and opiates interfere with the immune
system. Opiates increase apoptosis (cell suicide) of T-lymphocytes
from the norm of 5% to 30%. Additionally, multiple chemical
sensitivities and liver pain would likely result.

Metallothioneins (MT) are small (short) cysteine-rich proteins that
do more than just help cells detoxify, scavenge free radicals, and
regulate metals. They are involved in cell growth and cell
specialization (differentiation) and homeostasis. Growth factors such
as epidermal growth factor (EGF) cause rat liver cells to grow and
secrete MT. Zinc also stimulated MT and EGF+ zinc made the effect
additive (the EGF effect plus the zinc effect). It is believed that
lots of growth factors that influence liver regeneration play a major
role in regulating MT synthesis and secretion.

William Walsh, senior scientist, Health Research Institute and
Pfeiffer Treatment Center of Naperville, Ill., in his study of 503
children with PDD, Asperger's, and autism, found all but four were
missing MT, which the body needs to bind with toxic metals-like
mercury-so it can be excreted before it damages the brain and gut.
Walsh believes a child who lacks MT may develop any of these
developmental conditions if he gets mercury in his system. This may
explain why some children become autistic after receiving a mercury-
enhanced vaccine. It also explains why autism hits before the age of
3. After that, the brain and the gut have matured enough to withstand
further doses of mercury, although the child may develop ADD and
lesser developmental problems.

Glutathione (along with L-histidine and zinc) is a key resource for
the formation of metallothionein (MT). This molecule prevents
cellular toxicity by creating a stable storage molecule for excesses
of both essential minerals such as copper and zinc, and toxic metals
such as mercury and cadmium. In 1995, Sato et al. reported that
inhibition of glutathione-S-transferase induces decreased expression
of MT. Walsh recently reported that 91% of autistic patients had a
deficiency of metallothionein, and suggested this deficiency is
likely to be genetic, and may be a primary susceptibility factor for
neurotoxicity from heavy metals including vaccinal thimerosal. The
cumulative effects of ingesting mercury can cause brain damage.
Thimerosal, a mercury compound, is used as a preservative in
hepatitis B, diphtheria, pertussis and acellular pertussis, tetanus
and HIB vaccines. Most infants have received a total of 15 doses of
these mercury-containing vaccines by age six months! Studies document
thimerosal as both an allergen and a toxin to sodium channels.

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