Jonsher, I have used Barberry for quite a while, tincture. I have used a combination of herbs in a Nature's Secret product, called colon cleanse. I have use many combination of herbs over 40 years of my 60 year life. It's going to take someone with prior experience to get it right; someone who knows herbs, herbal combination, quantity and correct protocol. I've even tried Miracle-Mineral-Supplement for 10 months, the full course and back to daily maintenance. Miracle-Mineral-Supplement has been the greatest help; but only temporary. So, I've got something sinister going on. I'm tired of experimenting.