I've had a moderately severe case of Acne disappear almost instantly - one time overnight, the other time in about 2 hours while I was awake. Both times I was on extreme emotional highs and I seemed to clear some type of emotional blockage that is causing physical problems. My face became as smooth as a baby's bottom. My Acne is not the typical big zit type of Acne - it usually is smaller and not filled with fluid. Sometimes when I feel anxiety, instantly one of these things feels like a pinprick on my skin. My acne is definitley tied into emotional causes, although there may be physical reasons as well.