The complexity of these conditions are always measured by individual factors.
In my own case, I think the protozoa, are using up zinc reserves and starving the cells that need it. I can tell my zinc is low, when sex-drive is lowered. It always improves with supplementation. Sorry it's not very scientific, but it is a intuitive assumption based on practice.
The same goes for magnesium levels. When I have restless legs, magnesium supplementation quickly resolves it. Shroom