Update! Eyesight improving, and gene... 
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Just wanted to put an update!
I went to the optometrist a week ago and he informed me that my eyesight is improving, with a .50 shift in both eyes. I've been supplementing with Iodine since the start of the year (changing quantities to play with the detox, now on a pretty steady 125mg a day) and more recently also Borax (about two months in now, 1/8 tsp a day after a hell of a rocky detox start) - plus all the co supps.
Eyesight is improving dramatically, skin is looking amazing, my energy is finally starting to be more consistent, my concentration and focus are phenomenally better, there has been weight loss without any effort (though bloating comes and goes with phases of detox), and in general I'm looking and feeling younger, more vital, more alive.
Current side effects are: some hair loss, breasts and breast cysts (I have at least a dozen in each breast) seem to be swelling and hardening then softening and shrinking in cycles - I can't quite figure out if there's a "new normal" yet. And since being able to take the borax more regularly (the early detox was mega) my hormones must be doing some adjusting because I just had a super heavy and long period (mine are usually very brief and light), my boobs got HUGE this period, and my emotions are swinging a bit.
My decade long chronic thrush has yet to shift. With the borax so far the thrush is a lot worse - detox reaction? I hope? I'm using boric acid capsules for now.
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- Re: Update! Eyesight improving, and ... #39806
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This is a reply to # 2,413,285Hiya!
Grab strong vitamin A (Retinol, retinyl acetate, dunaliela algae are all excellent forms of it, especially the algae for a mood boost!). You can take it up over 50,0000 IU a day or higher for several weeks, (especially for very heavy periods and painful breasts) to destroy vital strongholds in the body. Give breaks though for your vitamin D levels to re-establish themselves though, since A and D are on a seesaw with eachother and A lowers production of red blood cells.
I especially recommend the dunaliela because it is cheap as dirt and has a lot more than just beta carotene to offer. Search the IodineVWT forum for Wombat's (and a few other) posts on vitamin A and women's health!
Vitamin A will help destroy the encystations. Zinc also comes to mind.
I'd like you to pay what vitamins/co-nutrients you are taking beyond the borax and iodine?
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- Re: Update! Eyesight improving, and ... trapper/kcmo
6 y
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MoreThis is a reply to # 2,413,349remember also that Iodine accentuates the effect of vitamin A and D. i found that Iodine made supplementing A and D much less critical and i could supplement less when needed. your mileage may vary.
- Re: Update! Eyesight improving, and ... Stargazer1111
6 y
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This is a reply to # 2,413,349This is dangerous advice. I study vitamin A in the field. Preformed vitamin A is markedly toxic and different people have different levels of tolerance for it.
Supplementing with vitamin A is quite risky. I have consulted with a group of doctors who are proposing that the FDA lower the RDA from 5,000 IU per day down to around 600 IU. They, and I, believe that people are chronically overdosing on it given that it is in most fortified foods and a lot of people take it in a supplemental form.
Getting anything over a few hundred IU per day of retinol is risky.- Re: Update! Eyesight improving, and ... #68716
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This is a reply to # 2,414,100it is speculation but looking at retinol molecule it clearly is an electron transfer agent, and being a terpenoid I would guess that if a person took enough of it, they could induce liver cancer. ok, now I'll go search for connection btw retinol and hepatoma- Re: Update! Eyesight improving, and ... Stargazer1111
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This is a reply to # 2,414,103Yes. The redox chemistry is what makes it so toxic. It creates an inordinate amount of free radicals that go on to produce reactive oxygen and reactive nitrogen species that induce cell death.
The brain and the gastrointestinal system are particularly sensitive to retinol.- Re: Update! Eyesight improving, and ... #68716
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This is a reply to # 2,414,107I don't know about that, it looks more like a free radical terminator to me, the radicals being terminated being peroxy and superoxy, which are essential for normal cell function. Destroy too many of those and you end up with unoxidized species normally oxidized in a healthy person, inhibit many essential processes in soft tissue. Free radicals are your friend, but only if maintained in their beneficial range of activity. A lot of "health" problems come from too few or too many, at the extremes. This is how people accomplish a metabolic shift, by enabling free radical activity to go too much, one way or the other. Nobody on earth knows all the details yet but we do know that shifting free radical activity too much one way or the other is "bad". Given retinol is never found alone in any natural food, and given its importance in electron transfer and ability to terminate free radical propagation, it makes sense that avoiding an excess of that stuff is probably smart. I generally try to keep excessive amounts of free radical terminators out of my diet. Based on normal levels, I sense the retinoids work together with mk4 mk7 and the tocopherols which are obviously semi-quinones. In the final analysis, I don't really know anything.- Re: Update! Eyesight improving, and ... Stargazer1111
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This is a reply to # 2,414,111The literature doesn't support this position. Retinol can only act as a terminator when it is properly delivered to cells by retinol binding protein. Retinol binding protein is a strong beta barrel protein that evolved to encompass the retinol molecule in order to protect everything else from the molecule. When free retinol is present, it haphazardly donates electrons to anything that will accept them in the vicinity, including oxygen, and oxidized metals. This creates the chain reaction that eventually ends up producing peroxynitrite and other reactive nitrogen species that then inappropriately signal apoptosis. Retinol is quite similar in structure to the polyunsaturated fats, another set of quite toxic molecules people consume too much of, in that they both contain a lot of electron-rich double bonds. These double bonds are easily peroxidized which produces a number of toxic byproducts. Retinol and the polyunsaturated fats are some of the most unstable molecules in existence.
Retinol is found in several foods disproportionately to its fat-soluble counterparts. Even grass-fed butter has markedly more retinol than it does vitamin K2 or vitamin D. Several studies have shown that it only takes a tiny amount of retinol to negate the benefits of moderately large doses of vitamin D.
Also, it is unlikely that humans evolved consuming much, if any, retinol in their diets as evidenced by the evolution of the beta carotene conversion pathway. Except for a few unlucky people who have genetic mutations, the majority of people convert beta carotene into retinol in a negative feedback loop that prevents the over-conversion of the beta carotene, thus preventing toxicity. The evolution of this conversion pathway suggests that humans evolved in retinol-poor conditions. Another piece of evidence suggesting this is the remarkably high absorption and storage rate (roughly 85-90 percent of retinol is absorbed and stored) and the extremely slow excretion rate. When I overdosed on retinol, I calculated a rough half-life that indicated that it would take about 4 years to excrete the 100,000 IU per day that I took for merely 5 weeks.
Retinol is dangerous and should not be supplemented with on a whim.- Re: Update! Eyesight improving, and ... #68716
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This is a reply to # 2,414,120OK professor. It seems you haven't stumbled upon the right literature yet. I don't come on here to argue about retinol, this forum is for Iodine support, like it says at the top of the main page. So don't be surprised if some moderator comes along and moves your postings to the vitamin A forum, if there is one. If there isn't a Vitamin A forum, you might consider to ask Webmaster to create one for you, then you can attract the right audience. Maybe start a Retinol Debate forum too, in case anybody cares to argue with you about it.
What's a retinol counterpart ? Which vitamin D molecule are you referring to ?
You might want to look into mesomeric induction before asserting retinol can't terminate radical propagation.
Counter to your assertion, retinol is nothing at all like polyunsaturated fats. Fats are glycerol triesters featuring lipid groups. Way different, even the soap chemists know that. Polyunsaturated oils are not all toxic as you wrongly assert, some are essential for life, some can be very beneficial. Neural tissue in the brain contains, help me out professor, how much EPA and DHA ?
I'd be interested in knowing your source for asserting what is unlikely with regards to evolution, and how the carotene pathway "evolved". Clearly thats nothing but conjecture. Most people coming on here seeking Iodine information probably aren't interested.
What ever motivated you to take so much retinol ? Thats an insane amount you took.
- Re: Update! Eyesight improving, and ... Stargazer1111
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This is a reply to # 2,414,128Your emotionally charged response was unwarranted and indicates your inherent bias.
Someone else took the forum off topic by suggesting supplementation of retinol. I study retinol as part of my academic work and responded with a word of caution.
Retinol's counterparts are the other fat-soluble vitamins, particularly vitamin D, but also vitamins E and K1/K2. There is an intricate relationship between all 4.
Your assertion that I asserted that retinol can't act as a terminator is a strawman argument. I never said this. Re-read my post.
Retinol is very much like the polyunsaturated fats in the manner in which I already characterized it. Both are extremely unstable because of their richness in double bonds. This is precisely why retinol binding protein exists. It encases the retinol molecule to prevent its premature and inappropriate oxidation. Free retinol is toxic and this has been demonstrated thoroughly in the literature.
The notion that polyunsaturated fats (PUFA) are necessary for life needs clarification. PUFAs are necessary for some organisms but not so for others, or if they are they are required in such minuscule amounts as to render a deficiency unlikely with a normal diet. The studies upon which this idea is based are flawed. The Burr studies that are often cited as the first evidence of "essential fatty acids" were debunked later after the discovery of vitamin B6. The rat acrodynia that developed in response to a polyunsaturated fat "deficiency" was later cured by adding vitamin B6 to fat-free chow. The mechanism by which polyunsaturated fat reverses the acrodynia is by sparing vitamin B6. Thus, the true deficiency is in vitamin B6, not PUFAs.
I believe you need to study evolution a little more closely. In a retinol-poor environment, the carotene-conversion pathway would have been selected for because it would have given those people a reproductive advantage over those who could not convert carotene. Additionally, those who could absorb and store retinol more efficiently would have been selected for because this also would have given them a reproductive advantage. The carotene conversion pathway exists because at some point in our evolution there was a mutation in an individual allowing them to convert carotene into retinol. This was selected for over time and those who could not do it were selected against because retinol was so rare in the environment. This is how natural selection works. I am a biochemist. I have spent years studying this. Taking people who evidentially evolved in a retinol-poor environment and proceeding to fortify foods and recommend foods naturally high in retinol along with vitamin supplements will cause both acute and chronic toxicities- Re: Update! Eyesight improving, and ... #68716
6 y
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- Re: Update! Eyesight improving, and ... Stargazer1111
6 y
1,430
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- Re: Update! Eyesight improving, and ... #68716
6 y
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This is a reply to # 2,414,153No, It shows that you're off-topic and disruptive. Why would I want to argue with any of you all ? You are free, now go bother some other forum, ok ?
- Re: Update! Eyesight improving, and ... #68716
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- Re: Update! Eyesight improving, and ... Stargazer1111
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- Re: Update! Eyesight improving, and ... #68716
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This is a reply to # 2,414,142I didn't write it, and you don't have to like it. I hope you didn't hurt yourself taking all that retinol. I'm not smart enough to understand all this, but maybe you or Trapper can:
Cancer and Vitamin A
Vitamin A intake has a complex relationship with cancer prevention: while small doses of vitamin A or beta-carotene appear to help prevent cancer, higher doses seem to have the reverse effect. The anti-cancer effects of beta-carotene appear to stem from its anti-oxidative ability to scavenge for reactive oxygen species, as well as through its conversion to vitamin A, which can improve immune function in addition to eliciting an anti-proliferative effect through the RAR and RXR receptors, thereby acting to block certain carcinogenic processes and inhibit tumour cell growth. However, an excessive intake of beta-carotene appears to have carcinogen effects, possibly through its promotion of the eccentric (or asymmetric) pathway of beta-carotene cleavage, which produces breakdown products that might lead to the destruction of retinoic acid through the activation of the P450 enzyme, which in turn could decrease retinoid signalling leading to enhanced cell proliferation. Therefore dosage seems to be an important factor in beta-carotene action.
https://www.ebi.ac.uk/interpro/potm/2005_6/Page2.htm
- Re: Update! Eyesight improving, and ... Stargazer1111
6 y
1,391
This is a reply to # 2,414,155This article supports my position on higher amounts of vitamin A. Are you trying to use it to refute my position? It clearly doesn't.
The problem is what constitutes an overdose for one person may not for another. Retinol-binding protein levels are highly individual. Some people make more than enough and some people are quite deficient. Those who are deficient, particularly due to a disease process, can develop retinol toxicity at even normal or below normal retinol intakes.
- Re: Update! Eyesight improving, and ... #68716
6 y
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This is a reply to # 2,414,156whoever you are, I don't want to argue with you about retinol, I have far better things to do, like clean my trash cans.
I'm glad you like the article. I hope it makes you happy.
Have a nice day.
- Re: Update! Eyesight improving, and ... #68716
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- Re: Update! Eyesight improving, and ... Stargazer1111
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- Re: Update! Eyesight improving, and ... #68716
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- Re: Update! Eyesight improving, and ... trapper/kcmo 6 y 1,465
- Re: Update! Eyesight improving, and ... Stargazer1111
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- Re: Update! Eyesight improving, and ... #68716
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This is a reply to # 2,414,120As long as we're off topic outside the galaxy, here's an article authored by a neurosurgeon explaining the benefits of a couple of polyunsaturated fats which are found in high concentrations in the brain. Merely because a molecule contains conjugated ethylenic linkages does not mean the body will quickly turn those linkages into peroxidated forms, there is much more going on in the body, so blanket statements like the one you'd writ should be scrutinized a little better. There are a lot of molecules in the body that are not very stable outside its environment but that's not really important, what is important is sometimes knowing what they are, this enables a clue to theorize what might be happening. It is a normal part of metabolic energy production for oxygen to add to those ethylenics. Here's the article, I bet the audience will find it interesting and I apologize for going off topic but couldn't resist refuting your statements, I wish this stuff were that simple.
Here's a quote from Blaylock's article, concerning those dangerous unstable polyunsaturated fats known as EPA and DHA: "Some 70% of energy supply during fetal development is devoted to brain development, and lipids make up 50 to 60% of the structure of the brain, with DHA making up 30% of the brain and 50% of the retina’s structure."
http://www.lifeextension.com/magazine/2008/1/report_dhafishoil/page-01- Re: Update! Eyesight improving, and ... Stargazer1111
6 y
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This is a reply to # 2,414,130Dr. Blaylock has always been apocryphal and I am quite skeptical of his claims. This is the same doctor who believes that vaccines cause autism, Parkinson's and ALS despite mountains of evidence debunking this claim.
There is a wealth of studies in Pubmed demonstrating that PUFA concentrations above 2% of calories result in lipid peroxidation and lipid peroxidation is one of the greatest predictors of shortening lifespan in animals. There is also a wealth of studies demonstrating the superiority of saturated fatty acids due to their lack of peroxidizability, even going so far as to cure liver disease. PUFA concentrations up to 2% of calories (so for someone like me, that is about 5 grams per day while the average consumption in the US is something like 35 or 40 grams per day) merely results in the production of the "highly unsaturated fatty acids" (HUFA) that are incorporated into cell membranes. Anything above this concentration is oxidized for energy and it is the oxidation for energy that is dangerous and results in peroxidation.
Saturated fatty acids cannot peroxidize and monounsaturated fatty acids only peroxidize at a rate of something like 1-2%. On the other hand, polyunsaturated fatty acids peroxidize something like 35-50% of the time. Lipid peroxidation is a large component of neurodegeneration. By the way, a DHA "deficiency" can be relieved by eating as little as 0.2% of calories as omega 3, making a DHA "deficiency" highly unlikely for most people.
The majority of the fats in the diet should be saturated and PUFA should be minimized.
https://www.ncbi.nlm.nih.gov/pubmed/20509914?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/16108051?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/15051845?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/7615205?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/17313679?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/15757684?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/17928583?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/19190032?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/11755312?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/22543624?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/21558243?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/21904609?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/13637997?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/20102846?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/9478042?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/12848297?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/19356914?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/19923368?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/8911273?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/9351376?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/5900208?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/18070879?dopt=AbstractPlus
https://www.nap.edu/read/10490/chapter/10#493
https://www.ncbi.nlm.nih.gov/pubmed/19818397?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/20621447?dopt=AbstractPlus
https://www.ncbi.nlm.nih.gov/pubmed/12571649?dopt=AbstractPlus
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