Re: Metformin slows growth of tumors lacking p53

yes, my mom was told to take it after meals, too.  and she was told to take one big dose like that.  later i think they had her take it two times a day. 

The average dosage unless the physician indicate otherwise is the following- 1 or 2 tablets following each of the three main meals.

i think the theory is that the food doesn't raise the blood sugar right away, so it is ok to take it after meals.  or, perhaps they don't want you getting your blood sugar too low (since there is no food in your stomach, it could happen).  plus, metformin can supress appetite and maybe a person would not end of eating or eating that much.   

BUT, i did find this:

A. Comparative studies have not been done. At the low doses of dilantin that we recommend, side effects are generally non-existent. (Dilantin ® 200-300mg daily can significantly improve the Chol/HDL ratio).

I have used Dilantin ® (Phenytoin) and Metformin together for years (and have recommended this regimen to many patients, as well). Dilantin ® and Metformin can be taken with meals or on an empty stomach. Unlike other oral anti-diabetic agents, these substances do not cause hypoglycemia-in fact, they are helpful for those with hypoglycemia, as better use is made of the available glucose.

No problem taking them in conjunction with HGH.

Ward Dean MD

http://www.antiaging-systems.com/qanda.htm

myself, i take it at the same time as meals 2 to 3 times a day and have for 3 years.