For me, I did The Master Cleanse and it did not help or cure the Lyme, although I had moments of feeling better. I also did a completely raw diet for many months and all sorts of supplements. This also didn't work for me.
That's not to say it won't work for you or other people. I thing with Lyme especially, people are different, with different co-infections and viral loads and parasites, etc and can handle different things at different times in the recovery process.
Now that I am feeling somewhat better through other treatment, I may revisit fasting, et al. But there was a time that all that stuff just made me sicker because my body was *so* rundown that everything I did made it worse, including fasting and Liver Flushes and other detoxing.