Re: [cancercured] ASA helps prevent breast cancer?
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This is a reply to # 753
Re: [cancercured] ASA helps prevent breast cancer?
To:
From: "MJ"
X-Yahoo-Profile: mjb5123
Date: Tue, 15 Apr 2003 23:46:34 -0800
Subject: Re: [cancercured] ASA helps prevent breast cancer?
Neil, Helen,
Here is a bit more info about this study.
http://www.medscape.com/viewarticle/452070
____________________________________________________________
Strong Inverse Link Between Breast Cancer and NSAID Use
By Megan Rauscher
NEW YORK (Reuters Health) Apr 08 - There is "compelling and converging
evidence" that regular use of nonsteroidal anti-inflammatory drugs (NSAIDs)
inhibits the formation and growth of breast tumors, Dr. Randall E. Harris of
Ohio State University told Reuters Health.
The latest evidence comes from the Women's Health Initiative (WHI), a large
prospective study of more than 80,000 postmenopausal women who had no
history of cancer at baseline and who provided comprehensive health
information including data on Breast Cancer risk factors and use of aspirin,
ibuprofen and other NSAIDs.
During an average follow-up of 4 years, 1392 developed breast cancer. In
analyses researchers noted a statistically significant inverse linear trend
between Breast Cancer and the duration of NSAID use (p < 0.01).
Taking two or more NSAID tablets per week (aspirin, ibuprofen, or related
compounds) for 5 to 9 years reduced the risk of breast cancer by 21%.
Extending NSAID use to 10 years or more led to an even greater risk
reduction of 28%.
Specifically, "aspirin had about a 22% risk reduction effect and ibuprofen
had a 49% risk reduction effect," Dr. Harris said. The result with ibuprofen
is "striking," he told Reuters Health.
Importantly, the protective effect held in analyses adjusting for age and
other breast cancer risk factors, including high body mass index, estrogen
use, family history, parity, and exercise.
These reductions were achieved with standard doses of these compounds
(aspirin, 325 mg and ibuprofen, 200 mg). Regular use of low-dose aspirin
(<100 mg) did not lower the risk of breast cancer.
"Interestingly, we did not see an effect for acetaminophen," Dr. Harris told
Reuters Health, probably because acetaminophen does not block
[cyclooxygenase-2] COX-2, which is blocked by aspirin and ibuprofen. "COX-2
is the trigger for inflammation and I believe inflammation is a major
component of carcinogenesis," he said. COX-2 is overexpressed in most human
breast carcinomas.
These findings "set the stage" for clinical trials of selective COX-2
blockade in cancer prevention and therapy, he added.
Dr. Harris was scheduled to present the findings during the American
Association for Cancer Research's 94th Annual Meeting in Toronto this week,
but the meeting was postponed due to the outbreak of severe acute
respiratory syndrome (SARS).
Miki
http://www.medscape.com/viewarticle/452070
-
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