Thank you Krupaclassy, for your reply. I would really be interested in hearing your story about the Downs child who started glyconutients and has done a great turn around. My daughter does have the weight gain, and the Acne on face and back. Please explain what you mean by Glyconutrients. She takes tons of vitamins, minerals and herbs as well as she's taking Paxil for anxiety and Armour for a low thyroid. Just last month she had her first vaginal yeast infection and had to take Difulcan to clear that up. One of my other daughter's, at 26, has Endometriosis and ovarian cysts. She's had several surgeries to remove these and they've always grown back. Maybe this is a sister thing. Although I have two other daughter's that don't seem to have these problems. One thing about my DS daughter is she rarely complains of any pain. During her usual periods for years she would have some cramps the first and second day, but not severe. This last unusal one she had no pain at all. Oh yes, I forgot, she also takes Piracetam for brain stimulation.