Derek-I sent a post earlier, sorry I guess I sent it into cyberspace somewhere! ha ha. When the Grapefruit-Seed-Extract stopped working for me I quickly went way down hill. I tried some other antifungals but did not get good results. I liked North American Herb and Spice companys oil of oregano but if I took it for more than a few days it would burn my intestines really bad. I never got any effect again unfortunately when I tried Grapefruit-Seed-Extract again. Something kind of interesting is that my daughter suffered for years with almost constant ear infections but after I began giving her a half-pill a day for about 5 or 6 months of the Grapefruit-Seed-Extract she immediately improved and has not had another infection in over a year!! { I'm sure she still has candida issues but I seem to have broken that ear infection cycle .} Somebody else said this the other day and I think they are probably right that antifungals don't work. From my experiences I think what happens is that the "nasties" just branch off someway and create a new strain resistant to the antifungals-BUT with that said the improvement in my daughter shows maybe it's worth trying for a little while { I think she is not quite as sick as me and maybe it has not become systemic?? ) PS. I've had about 16 colonic tratments recently and am about to try a liver flush. Sorry this is so long-just trying to be thorough. Hope this helps!