Inasmuch as it may relate to your proposed study, I find your initial post to be one of the most significant ever posted here. Looking forward to future submissions from you with great anticipation. I'm 49, male, 5'11", 360, living with peripheral arterial disease and sciatica --- every time I summon the courage requisite to flush, it's a weekend of severe pain or mobility issues. Your mention of pear juice, however, is somewhat encouraging for this hesitant, weary man. Regards from South Texas. /Tom