I would agree with the ashwaganda warning, I took a low dose for 1 week and felt quite jittery, however I do not have a problem with nightshade family - It's probably dose dependant, ashwaganda supplements are highly concentrated with withanolides whereas the dried root is not and you would need much more of the stuff to get the same affect, and not all withanolides are beneficial. Withaferin A is one withanolide that is cytotoxic, as has been established in multiple scientific studies. So, it is undesirable to have Withaferin A in an ashwagandha extract when the intended use is for classical applications like building anti-stress ability, energy, cognition and immunity. Some ashwagandha extracts have high levels of Withaferin A because the manufacturers use ashwagandha leaves, instead of just the roots. Best avoided in my opinion.