WE at BiomagScience attribute this reaction to a hypo-adrenal gland condition because we noticed years ago about the response to long-term Bio-Negative on the adrenals. As a result of our research, we developed pads that did not have the negative facing magnets at the adrenal gland areas. We do not beleive it had anything to do with the melatonin levels - but rather a specific adrenal gland issue.