I feel bad for your wife and hope her levels don't get any worse. I have a similar kidney problem as my function kept dropping, too. So, my kidney doctor told me to try taking a product called Renadyl that is a mixture of different probiotics. It somehow uses the uremia waste for its food or something like that. Anyway, it's supposed to help reduce both BUN and Creatinine levels. In my case, it took about 3 months, but both levels dropped by about 15% and my kidney filtration rate stabilized. I was thrilled because I have not yet had to go onto dialysis and hopefully never will. It's been about a year now. You might want to check it out. I just ordered if from the Renadyl website. It's worth checking into if it can help you. I hope it works as well for her as it did for me. Good luck.