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Re: Cellulase ok??
 
dvjorge Views: 3,411
Published: 7 years ago
 
This is a reply to # 2,187,210

Re: Cellulase ok??


No.!! Don't take that. Those products using cellulase and hemicellulase claiming those enzymes digest candida cell wall are a scam. There are two products in the market that contains enzymes that really affects candida albicans cell wall. One of them is Interfase and the other I don't remember the name now but is very similar to Interfase. Interfase Plus is even better since they added EDTA.
You need to look to a product containing enzymes able to degrade Beta Glucan and Chitin.
Under stress, candida albicans increase chitin and glucan to reinforce its cell wall.

Interfase contains chitinase (chitosanase) and glucanase.

See it about Candex :

Candex contains the fibre digesting enzymes, cellulase and hemicellulase. The manufacturer claims because yeast cell walls are built mainly of fibre, which is mostly made of the complex carbohydrate, cellulose, cellulase and hemicellulase are capable of killing yeast.

However, a review of the scientific literature suggests that this mechanism of action is unlikely to be true. For while plant cell walls are made predominantly of cellulose, yeast cell walls are not (yeast are classified as fungi). For example, in the article, "Synthesis of the yeast cell wall and its regulation" in the Annual Review of Biochemistry, there is mention of many other complex carbohydrates found in yeast cell walls, but there is no mention of cellulose[1] nor is cellulose mentioned as a cell wall component in candida albicans, the yeast strain most frequently associated with human fungal infections.[2] Indeed, scientists have even modified yeast cells so they can make their own cellulases. This allows the modified yeast to ferment widely available plant material, which is made mostly of cellulose, and turn plant cellulose into alcohol for biofuels (cellulosic ethanol). One scientific article even called yeast an "ideal host strain" for producing cellulases.[3] This is consistent with cellulase not being toxic to yeast and no mention was made of any toxic effect of cellulases on the modified yeast.

However, there is evidence chitinase and glucanase affect the yeast cell wall.

See this abstract :

Summary
Plant chitinases and β-1,3-glucanases have been demonstrated to inhibit fungal growth in model experiments, both on agar plates or in liquid media. Here,Trichoderma longibrachiatum was taken as a model to study the morphological changes caused by chitinase and glucanase treatments, using cytochemical techniques in combination with fluorescence and electron microscopy. Chitinase, alone or in the presence of glucanase, arrested growth of the hypha: it affected the extreme tip of the fungus producing a thinning of the wall, a balloon-like swelling and a rupture of the plasma membrane. Chitin and glucans were present in the wall, as shown by lectinand enzyme-binding experiments, but they had a different susceptibility to chitinase and β-1,3-glucanase. Chitin was present at the apex and in the inner parts of the lateral walls; it was more susceptible to chitinase at the tip than in the subapical part. Glucans mostly occurred on the outer layer where they were degraded by glucanase. The latter did not affect the inner hyphal skeleton. It is suggested that the growth inhibition ofTrichoderma by hydrolytic enzymes is the consequence of a thinning of the cell wall in the hyphal apex, leading to an imbalance of turgor pressure and wall tension which causes the tip to swell and to burst.

Jorge
 

 
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