"There have been a few reports in Japan of a rare condition called insulin autoimmune syndrome in people using alpha lipoic acid.[citation needed][51] The condition causes hypoglycemia and antibodies directed against the body's own insulin without previous insulin therapy."
Sounds like it's unusual. Rare, even. So it's not a normal "depletion".
Also, we have to be careful. There are two different ALAs. Alpha-linolenic acid and alpha-lipoic acid. They're both called ALA. Probably we should refer to them by their long names to avoid confusion.