Re: Copper, cortisol, bile etc.

When I take B5 (I started at 100mg in the morning), I feel more edgy, I feel like I need to eat carbohydrates more often, I seem to piss more bubbles (which correlates with collagen loss) and I generally feel like I'm slightly clumsy and bumbling, as if I'm rushing, but I'm not.

The fact that I seem to need more carbs and pee more bubbles/foam implies to me that my problem is ramping up rather than abating.

The B complex is a tricky issue - I can't take niacin/B3 because it causes flushing, which is bad for me with compromised vascularity. Anything that serves as some kind of vascular modifier seems to harm me. I would consider a B complex with niacinamide, but I can never seem to find a decent one with good amounts of everything. I was thinking about buying separate B vitamins and complexing them myself, but it's time consuming to manage that protocol and dose up/down accordingly.

I'm aware that copper can damage tissue, but it's not "free" most of the time. The times I've noticed that it's freed is when I use a chelator like zeolite, which literally pulls it from storage and stirs up the ions, which I feel as pin pricks and maybe damage in certain places.

When I say my cortisol rages, it's almost like I can feel the catabolism, particularly to my skin - I lose substance and elasticity so rapidly sometimes that I can almost feel my skin folding differently from one part of the day to the next, particularly on my hands and neck. I'll look at the hand and it's suddenly become more crepey - I observe this more when I'm taking something like B5 at 500mg.

What do you mean my adrenals are "in bad shape"? I don't understand the concept of bad shape - why would they respond erratically to the hormone precursors that they need. Aren't they just a dumb end organ controlled by the brain's hormones anyway? The adrenals just do as they're told by the brain, whereby their only limitation is the amount of raw material available. If you then add more raw material, the adrenals can respond more to the flurry of signals via the brain's hormones and output more hormone in a certain pathway.

If the brain is receiving signals from the body to stimulate cortisol production (e.g. from pro-inflammatory cytokines), the brain tells the adrenals to kick out as much cortisol as it can produce with the raw materials it has.

Conversely, in the case of low cortisol, it would either be that the brain is not giving enough signals to the adrenals or the adrenals are somehow not hearing the signals (e.g. blocked adrenal receptor sites).

My question is, is my brain sending my adrenals signals to make cortisol for a reason, or is the feedback mechanism in my body for cortisol damaged or upregulated.

How could the adrenals be screwed if they can spew out a ton of cortisol in response to a body stress like psychological/trauma or chronic infection?

I just don't understand how the adrenals are unhealthy if they can produce lots of cortisol...

Cortisol is associated with destructive collagen metabolism.

I was wondering if it's actually copper toxicity that's keeping my cortisol high and paradoxically, high cortisol preventing me from binding and using/excreting unbound copper.

I do feel copper leaving my tissues in a safe, controlled way when I take bile acids though. Something that baffles me is why can ceruloplasmin suddenly bind copper when bile acids are brought in from outside the body, if the adrenals are intimately involved? That's why I was asking about cortisol's effect on bile recycling between enterohepatic circulation and the liver/gallbladder.

If I take TMG or taurine, I also feel copper safely leaving binding sites. This is in contrast to a forceful chelator, which pulls metals out in an uncontrolled way, which gives me painful skin sensations and all kinds of nasty brain damage (which has stopped me breathing and given temporary paralysis on a couple of occasions for a few seconds).

It seems to me like just stimulating bile flow is a way to get the body to produce ceruloplasmin and pull copper from binding sites.

I just don't know about taking zinc, other than from my red meat. I'm concerned that I can't absorb copper anymore due to that soil organism and if I further antagonise copper, it may push me down a terrible road.

Sarah Myhill offers some DMSO-Copper Sulphate transdermal drops, which would ensure I get copper through the skin, but I'm not sure DMSO would be safe, never mind adding more copper into the equation that I may not be able to bind and use.

The unbelievable paradoxes of this scenario are baffling.

I wish I could have some hindsight from a computer simulation. Tweet