Copper, cortisol, bile etc.
Hey all,
I'm really, really puzzled...beyond puzzled - bamboozled...
I'm high cortisol, high unbound copper, low bound copper, low ceruloplasmin...
When I take ox bile, I get copper dumping symptoms, although I'm barely improving. I don't think the dumps are major, but they are consciously noticeable.
I was reading that apparently, more cortisol pushes bile acids out of circulation and into the gallbladder, which implies that cortisol controls bile recycling/availability between blood and liver (gallbladder storage).
Also, I notice that taking glycine and/or taurine causes copper dump symptoms, if again just mild.
Something else I noticed is that if I'm eating fat between doses of the bile factors, I get copper dumps.
One thing I don't understand is if my adrenals are weak and so not doing their job of telling the liver to produce ceruloplasmin, why can they produce high cortisol? Or, is it possible that my adrenals are just busy all day making cortisol, so having no time for anything else?
Is high cortisol, low DHEA and mediocre aldosterone (for the last 12-24 months) an indicator of adrenal weakness/fatigue or dysregulation because of a massive stressor like a gut infection?
My intracellular copper is now massively deficient to the extent that none of my copper enzymes are working. This is a nightmare for collagen, especially because I have no Zn/Cu-SOD to protect me from pro-oxidants anymore.
Something that I wonder is actually if high unbound copper is keeping my cortisol high and as I gradually remove unbound copper, the copper will gradually become more available. Is is rational to have to remove copper to ultimately make it more available?
This copper thing really baffles me. I'm scared to antagonise copper in case the remaining bound copper I have gets lower and then I really start to fall to pieces within hours or minutes rather than days or weeks.
Can we have a really thorough discussion about the dynamics of copper absorption, binding/transport, antagonism etc. please? I'm still largely confused about the whole "remove to make more available" notion.
It'd be great if anyone can elucidate this topic for me please...