i used methyl b 12 with disasterous result combined with folic acid it raises histamines. i was 80% better then started high doses and almost all my symptoms came flooding back in 5 days...tested my histamines and they were very high.high histamines go hand in hand with biounavailable copper. i've been on a Low Histamine Diet taking methionine and high dose vit C and plenty of water and i'm 60 percent there now....it was a massive discovery for me and is the missing link to get me to 100 percent i believe. my high histamine symptoms resemble low blood sugar, i get heavy limbs, poor balance, disoriented, derealization, constant hunger, hieghtened hearing and anxiety from the adrenaline surges my body is sending out to lower the histamines and a vibrating/buzzing and burning sensation. sometimes when it's really bad i wheeze and have air hunger