Toxic metals can be a big problem for these people, and research has found that copper, only when toxic can trigger this as well as other toxic minerals. Testing with Trace Elements Inc would be a good start.
My suspicion is that the onset was precipitated by stress in which magnesium plays a key role in nervous system health and its loss is profound in stressful events.
Vitamin D also plays a key role in both calcium and magnesium levels. Again, Magnesium is probably low due to her stressful events and Americans never get it in diet (at least most do not) - low levels of magnesium will alter the nervous system and stress levels. Look for a high quality supplement like UltraMag from Source Naturals http://www.ncbi.nlm.nih.gov/pubmed/2077436