Candida “Biofilm” – Have to Beat a Diverse Community

11 Dec19 Candida “Biofilm” – Have to Beat a Diverse Community

http://www.ncbi.nlm.nih.gov/pubmed/21875945

Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies
Excerpts:
…wild yeasts preferentially form surface-associated communities, such as biofilms and colonies, that are well protected against hostile environments and, when growing as pathogens, against the host immune system.
…a biofilm yeast colony is a finely tuned, complex multicellular organism in which specialized cells jointly execute multiple protection strategies.
… two mechanisms act in concert during colony development, allowing growth of new cell generations in a well-protected internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections.