Re: Update and new discovery

Histamine levels are intimately connected with copper....you may want to investigate that.

And taking zinc seems to have been very helpful to me, so this could be what's going on.

Also a chronic wound could cause histamine to be continually released, and hyperventilating?

No obvious chronic wounds (and the runny nose was always acute (happening with meals), not particularly chronic), and no hyperventilating.

Also estrogendominancedoes not mean high estrogen, just an imbalance of hormones where estrogen dominates

Right, sorry. I'd read about aging female estrogen dominance being a product of the relatively faster drop of progesterone.





So I suppose even with normal estradiol levels I could have even lower levels of other hormones. Since Adrenal Fatigue impacts hormone production... Let's look into this.

I do believe I have low aldosterone (resulting in dehydration) and occasionally low cortisol (resulting in sore joints, hypoglycemia, and other symptoms) (though I also have occasionally high cortisol). Low aldosterone and cortisol are common in "Adrenal Fatigue".





Some part of the path to aldosterone and cortisol may be bad.

Since my estradiol and DHEA levels showed up as squarely in the acceptable ranges, I'm guessing the pathway leading over to estradiol and DHEA is working okay. (My overall cholesterol levels were fine, too, so the problem isn't from higher up the path.) So it could be there's a problem in the path from pregnenolone → progesterone → aldosterone or pregnenolone → progesterone → cortisol. These both go through the adrenal glands, so it makes sense to implicate the adrenal glands as part of the problem, perhaps thinking they're fatigued.

But it may also be possible that the pregnenolone → progesterone step is screwed. If I have high histamine levels (postprandially) and they're caused by an estradiol:progesterone imbalance, and my estradiol levels are normal, then my progesterone levels may be low. And if progesterone is needed for aldosterone and cortisol, then low levels of progesterone could result in low levels of aldosterone and cortisol. Low levels of progesterone fits the puzzle of low aldosterone, low cortisol, and estrogen dominance (thus "histadelia").

Further reading shows that progesterone is produced in part in the adrenal glands. So putative low levels of progesterone could still be resulting from the same, single cause of low aldosterone and cortisol (i.e., the adrenal glands performing poorly could be causing all three hormones to be low). Though I found another description saying "progesterone is synthesized in the brain, spinal cord, and peripheral nerves from pregnenolone" and so by omission the adrenal glands are implied here not to be a substantial source of progesterone.

I'll look into how progesterone is really made.