Re: atherosclerogenesis

 The reading discusses multiple atherosclerogenic points of origin, alluding to the unique nature of development. However, there must be a source of major atherosclerosis common to many groups. The presence of immune system cells suggests arterial walls may contain infectious or toxic material, enticing the immune system to take action. Perhaps a continuous barrage of infectious or toxic material perpetuates atherosclerosis and growth of affected area.

What do you think is the major cause of atherosclerogenesis?

There is not a singular major cause.  Bacterial infections have been implicated as well as xanthine oxidase from milk.  Hypothyroidism is a major cause as this increases inflammatory homocysteine.  Hyperthyroidism due to the increased stress on the cardiovascular system.  High blood pressure and diabetes can damage arterial walls leading to inflammation.  Animal proteins contain arachidonic acid that is pro-inflammatory...........

Poor diet, low antioxidants, subclinical infection, toxic/toxin exposure, genetic anomaly, or other factors are my immediate guess. Taking poor diet, low antioxidants, and high toxic/toxin load into consideration, it may manifest as an opportunistic environment for a subclinical infection that eventually shows up as fatigue, susceptibility to flu/colds, slow healing, and other seemingly unrelated symptoms like GI disturbances. What's your take?

Again there are multiple causes.  But immunity does play a role.  I have another medical article that does in to this.  Let me see if I can dig it up again and post it.