atherosclerogenesis

The reading discusses multiple atherosclerogenic points of origin, alluding to the unique nature of development. However, there must be a source of major atherosclerosis common to many groups. The presence of immune system cells suggests arterial walls may contain infectious or toxic material, enticing the immune system to take action. Perhaps a continuous barrage of infectious or toxic material perpetuates atherosclerosis and growth of affected area.

What do you think is the major cause of atherosclerogenesis?

Poor diet, low antioxidants, subclinical infection, toxic/toxin exposure, genetic anomaly, or other factors are my immediate guess. Taking poor diet, low antioxidants, and high toxic/toxin load into consideration, it may manifest as an opportunistic environment for a subclinical infection that eventually shows up as fatigue, susceptibility to flu/colds, slow healing, and other seemingly unrelated symptoms like GI disturbances. What's your take?