moxidectin - info gathered

The "I" in this info is not me, it is someone on a forum on the net.



Severe reactions or intoxication can be reversed with alpha 2 agonist inhibitors such as yohimbine or atipazole. The product information for Mitaban shows an increasing frequency of side effects as the topical concentration increases. Interestingly, none of the dogs treated with the 1250-ppm amitraz solution (i.e., five times the approved concentration) applied to half of their body daily developed side effects."' In that study, however, one human being showed signs of respiratory distress after being exposed to a dog just treated with amitraz solution. Drugs such as hydroxyzine should not be used with amitraz dips, because they both have a monoamine oxidase-inhibiting activity that may potentiate toxicity.

interesting thread on microfiliariae as a coinfection of chlamydia pneumoniae, Lyme, and other chronic infective diseases: http://www.cpnhelp.org/microfilariae_more_body_s
. The recommended treatment is
ivermectin, which is interesting because many sufferers are finding ivermectin to be only partially curative; many more seem to be finding significant improvements from fenbendazole, moxidectin (myself), or praziquantel (people other than myself). It is interesting to note that the world health organization has found ivermectin to be ineffective as well, which is why clinical trials on Moxidectin and others are underway ( http://lymebusters.proboards39.com/v45index.cgi?board=rash&action=display&thr...
).
"I took a once daily dose of 12mg of Stromectol (I am @ 165 lbs) for 14 days. We followed this up with 2 weeks of a single 12mg dose once a week to be sure to kill any offspring (demodex have a 2 week lifecycle as I understand). I kept a list of my reactions during treatment, and I've always wondered, given some of my reactions, if it wasn't actually killing something in addition to the demodex."

"... the evidence that microfiariae are found in chronic fatigue is about to be published in mainstream journals. My doctor has been sending videos of the blood of his ME/CFSi patients to Dr Harvey's team in America, they are looking at fatigue disorders. I don't have any pictures but there are references in Pubmed to findings of microfilariae in the CNS, brain cysts, breast cysts and most other areas of the body http://tinyurl.com/2xrkez
and of microfilariae involved in other conditions http://tinyurl.com/2hfhka"


I'm running out of steam, but will summarize that I had a major Arthritis attack after presumptively treating Giardia, acquired in St. Petersburg, Russia, about a year ago with Flagyl. My positive ANA led me to a rheumatologist, who insisted I couldn't have Lyme disease due to my incomplete response to a monthlong course of doxycycline, and inconclusive blood tests. Connective tissue diseases have been present in several generations of my family, and we chalked it up to that. I began taking Plaquenil and Etodolac with partial relief, but still significant Arthritis in the left ankle, with a lot of swelling.

Then I began to be awake all night with itching. The horrendous rashes, with an apparent "trail", made me think I had scabies, but multiple permethrin and stromectol treatments only seemed to keep it "at bay". I still have multiple skin lesions and horrific scarring. I extruded huge amounts of black and blue fibers for several months.

A dermatologist diagnosed me with Lyme disease and opportunistic scabies, and I started Doxycycline for a 3 month course (which she feels cured her Lyme meningitis). Symptoms improved a bit, but with the ankle and foot swelling still significant. That has receded somewhat with the addition of Zithromax for the past 2 months. The peripheral neuropathy remains bad, though.
Abstract

A study in healthy male volunteers was completed to evaluate the safety, tolerability, and pharmacokinetics of a single oral dose of the antiparasitic moxidectin (MOX). This drug is registered worldwide as a veterinary antiparasitic agent for use in companion and farm animals. This is the first study of MOX in humans. All subjects were between the ages of 18 and 45 years, with normal cardiac, hematologic, hepatic, and renal function. Doses of MOX studied were 3, 9, 18, and 36 mg in cohorts of 6 subjects each (5:1, MOX:placebo). At the 9-mg and 36-mg doses, two separate cohorts were completed, one in the fasted state and one after the consumption of a high-fat breakfast. For all other cohorts, administration was in the fasted state. Safety and tolerability were assessed by physical examinations, ongoing evaluation of adverse events (AEs), and measurement of laboratory values. Pharmacokinetic (PK) samples were collected just prior to dosing and at various time points until 80 days postdose. Safety assessments from all dose groups studied suggested that MOX was generally safe and well tolerated, with a slightly higher incidence of transient, mild, and moderate central nervous system AEs as the dose increased as compared to placebo. The PKs of MOX were dose proportional within the dose range studied, and the elimination half-life (t1/2 elim) was long (mean: 20.2-35.1 days). At the 9-mg and 36-mg doses, a high-fat breakfast was shown to delay and increase the overall absorption but did not increase maximal concentrations when compared to administration in the fasted state. In summary, the results from this study indicate that MOX is safe and well tolerated in humans between the doses of 3 mg and 36 mg.

Quest Plus Gel Dewormer

Also Controls Tapeworms!
Quest Plus® Gel (moxidecin/praziquantel)

Combines 2% moxidectin and 12.5% praziquantel for the treatment and control of large and small strongyles, encysted cyathostomes, ascarids, pinworms, hairworms, large mouth stomach worms, stomach bots and tapeworms. One dose also suppresses strongyle egg production through 84 days. May be used in horses and ponies 6 months of age and older. Testing has not been done in breeding mares or stallions. Each sure-dial syringe is calibrated in 50 lb. increments, and treats up to 1,250 lbs. body weight.

FOR ORAL USE IN HORSES AND PONIES SIX MONTHS OF AGE AND OLDER
INDICATIONS:
QUEST PLUS (moxidectin/praziquantel) Equine Oral Gel when administered at the recommended dose level of 0.4 mg moxidectin/kg and 2.5 mg praziquantel/kg (2.2 lb) body weight is effective in the treatment and control of the following stages of gastrointestinal parasites in horses and ponies: Large Strongyles, Small Strongyles, Encysted cyathostomes, Ascarids, Pinworms, Hairworms, Large-mouth stomach worms, Horse stomach bots, Tapeworms.

One administration of the recommended dose rate of QUEST PLUS (moxidectin/praziquantel) Equine Oral Gel also suppresses strongyle egg production through 84 days.
Size: 0.4 oz (11.6 g) gel, Syringe is approximately 4" with a ½" tip.
A suitable macrofilaricide?
> A drug that is used in veterinary medicine
> has been shown to have interesting
> macrofilaricidal activity in animal models of
> onchocerciasis and lymphatic filariasis, and
> is now ready for evaluation in humans.
> Final results of moxidectin trials in animal
> models were presented to the TDR Product
> Research and Development Committee in
> March 2000. These preclinical studies have
> shown that the compound fulfils the criteria
> for a potential macrofilaricide (i.e. a drug
> that kills adult filarial worms) and has unique
> ‘selling points’:
> ** a single treatment produces ‘slow’ death
> of adult worms in girds and dogs, and sterilization
> of worms in cattle.
> ** compared to ivermectin (a microfilaricide,
> which kills larval stages of filarial
> worms), moxidectin has a considerably
> longer half life in plasma - 20 days compared
> to 2 days - allowing for the possibility
> of either less frequent treatment, or
> ‘higher efficacy’ with similar frequency of
> treatment, compared to ivermectin.
> ** it is effective in animal helminth infections
> that are resistant to ivermectin.
> Moxidectin is a fermentation product from
> Streptomyces cyaneogriseus spp noncyanogenus.
> Chemically it is related to other
> A suitable macrofilaricide?
> nematocides – the avermectins – but instead
> of a disaccharide side chain it has
> unique methoxine- and dimethylbutenylside
> chains.
> A suitable, safe and effective macrofilaricide
> would allow more impact to be made on
> controlling filarial diseases than is currently
> possible using microfilaricides, even though
> the latter are effective. This is because adult
> worms can survive in the human host for a
> number of years (more than 10 in the case
> of onchocerciasis) and treatment with
> microfilaricides has to be maintained for the
> lifetime of the adult worm.
> Currently moxidectin is only available in
> veterinary formulations, but discussions are
> under way with the company that produces
> them to obtain material for humans use. As
> soon as clinical grade moxidectin becomes
> available, clinical trials will start.
> WHO/TDR/Ottesen
> Adult filarial worm: the long search for a useful macrofilaricide may soon be over?

https://www.chicksaddlery.com/Merchant2/merchant.mvc?Session_ID=e47c14b42f119...

Saddle Tack Horse Supplies
Questions? 1-800-444-2441
After submission, you will be taken to a printable confirmation page. We will also send a copy of the order to the e-mail address shown above.

If in doubt about your order, please check your e-mail for confirmation.