Re: Sensitization to canditoxins causing vulvodynia.

By the time the IV drugs are used, the infection is already so severe that they don't usually cure it either.

Fungicidal in a test tube does not translate to fungicidal in a human body.

Also, resistance is well known for echinocandins, an even Ampho B.
Resistance to one drug in class usually means resistance to all drugs in class.

A lesson from a disease in the past

http://en.wikipedia.org/wiki/Leprosy


Until the introduction of treatment with promin in the 1940s, there was no effective treatment for leprosy. The efficacy of promin was first discovered by Guy Henry Faget and his co-workers in 1943 at Carville, Louisiana. In the 1950s dapsone was introduced to Carville by Dr. R.G. Cochrane. It is only weakly bactericidal against M. leprae and it was considered necessary for patients to take the drug indefinitely. When dapsone was used alone, the M. leprae population quickly evolved Antibiotic resistance; by the 1960s, the world's only known anti-leprosy drug became virtually useless.

THAT IS WHERE WE ARE TODAY WITH CANDIDIASIS

In North America alone, roughly 8 million cases of recurrent vulvovaginitis are reported annually, with more than 90% due to C. albicans.

http://www.internalmedicinenews.com/news/infectious-diseases/single-article/f...


"So the possibility of resistance is a tremendous problem and concern,"."Successful control, not cure, is achieved in more than 90%" [and the other 10% don't even achieve "control"]
8 Million have a chronic disease with no cure according to the article.

IS THERE HOPE?

Today leprosy is usually curable even in people genetically susceptible to it. How many Support Forums for leprosy? How many snake oil cures sold at amazon.com for leprosy?
How many leper colonies remain in U.S.?

SO MAYBE...

The search for more effective anti-leprosy drugs led to the use of clofazimine and rifampicinin the 1960s and 1970s.[71] Later, Indian scientist Shantaram Yawalkar and his colleagues formulated a combined therapy using rifampicin and dapsone, intended to mitigate bacterial resistance.[72] The first trials of combined treatment were carried out in Malta in the 1970s.

Multidrug therapy (MDT) combining all three drugs was first recommended by a WHO Expert Committee in 1981. These three anti-leprosy drugs are still used in the standard MDT regimens. None of them is used alone because of the risk of developing resistance.

NONE OF THEM IS USED ALONE BECAUSE OF THE RISK OF DEVELOPING RESISTANCE!

TODAY CANDIDIASIS (WHEN CHRONIC) HAS NO CURE!
BUT MAYBE Science WILL COME UP WITH A CURE.