Yes, after my first Liver Flush I spontaneously lost about 5 lbs and have kept it off. I am not overweight (maybe I could lose 5lbs more to be "Perfect" but who wants that?"), so 5 lbs was a good amount to lose overnight. It has been months since that first one, and it has stayed the same. I think it has to do with detoxifying and having your organs and system all working so much better.