This emphasis on the immune system is something I've been looking into more lately. I've been taking daily since around Christmas high doses of vitamin D3, and lately added zinc. I wonder if anyone could shed light on my reaction to a newer supplement I added. I got a combo capsule that has both astragalus and some medicinal mushrooms added. I did my research and all the mushrooms it contains kill candida, and are not supposed to worsen it. But when I take it, after an hour I get symptoms I've always associated with die off: a kind of restless anxiety, slightly increased heart rate, etc. Then it dies down and I feel pretty good. Doesn't seem to be an outright allergy, perhaps a sensitivity. I've never noticed a reaction to any antifungals I've taken setting in that fast.