Yes, constipation, bloating, and gas. It was really bad, even before the skin stuff showed up. Much of what kills the morgellon, also kills the good bacteria and makes the constipation problem worse. I started taking the anti-fungals in the morning and the probiotics at night. Buttermilk seems to work as well as or better than the probiotics I've bought. H202(food grade)enemas, Iodine enemas and smooth move tea, along with a diet high in greens and veggies, as much organic as possible. Also did a few rounds of anal ozone insufflation. Eating the inside of aloe leaves is also helpful.