Hi! I feel bad for you and the anxiety that you must feel in your house. I went through it terribly and can say for sure that your wife is suffering. When I mine hit i was about 45 although I think it started much earlier just not as noticeable. It got so bad that someone just walking in front of me was almost more then I could stand. Is your wife cold all the time, having heat flashes, dry skin, ridges in fingernails sensitivity to light, unable to think clearly, lethargic, low body temperature (under 98.6. After the birth of a child it can cause low thyroid and thus problems with estrogen dominence. It is a real and horrid problem. Low thyroid can cause so many problems and one of them is intolerance to stress. Check out Wilsons syndrome on the web and take her to one of those doctors that are listed. Make sure and interview them though as some of them will try everything but the kitchen sink and will end up costing you a fortune and you still won't be anywhere. I finally found a doctor in Saint Louis which is three hours from where I live and I can tell you it was amazing to feel normal again. My dry scaly skin is gone, my sunny disposition is back and I have the energy to take care of my family and my home. You have to follow the protocal by the letter and make sure the doctor you see orders the t3 from the pharmacy that they recommend. Order all the literature that they have, it is necessary to follow the protocal. It was several years of suffering before mine got straightened out and alot of people thought I was a hypochondriac. I remember when my brother said now thats the sister I remember. Your back! Good luck! What a great guy to research for your wife. You must love her very much. Sincerely, a healed mom & wife