OMG.......I suffered with so many symptoms during perimenopause. I was desperate to find an answer, I researched every article I could find on the web. I told my dr to use me as a guinea pig and do anything he had to do to get me back to feeling like me again. He decided to put me on Ortho Evra and wellbutrin. My life is back to normal again. I don't go through the ups and downs every month. I absolutely have no more symtoms during what should be my pms time. I recommend every woman who is desperate with pms symtoms to talk to their dr and request both Ortho Evra and Wellbutrin. I am amazed by the results!!!!!!!!!!