Niacin (vitamin B3) treatment can deplete choline
For TMAU sufferers, here's some info on Niacin (VIT B3).
http://en.wikipedia.org/wiki/Lecithin
NOTE: [regarding the intake of lecithin for people who don’t have TMA] Thus far, the only proven benefit and suggested use is for those taking niacin to treat high cholesterol. **Niacin (vitamin B3) treatment can deplete choline (vitamin B50), **necessitating an increased amount of lecithin or choline in the diet. CHOLINE AND LECITHIN PRODUCE TMAU SYMPTOMS.
http://wwwils.nlm.nih.gov/medlineplus/ency/article/002409.htm
Niacin (vitamin B3)
Alternative Names: Diet - niacin; Nicotinic acid; Vitamin B3
Niacin is a type of B vitamin. It is water-soluble, which means it is not stored in the body. Water-soluble vitamins dissolve in water. Leftover amounts of the vitamin leave the body through the urine. That means you need a continuous supply of such vitamins in your diet.
Function:
Niacin assists in the functioning of the digestive system, skin, and nerves. It is also important for the conversion of food to energy.
Food Sources :
Niacin (also known as vitamin B3) is found in dairy products, poultry, fish, lean meats, nuts, and eggs. Legumes and enriched breads and cereals also supply some niacin.
Side Effects:
A deficiency of niacin causes pellagra. The symptoms include inflamed skin, digestive problems, and mental impairment.
Large doses of niacin can cause liver damage, peptic ulcers, and skin rashes. Even normal doses can be associated with skin flushing. It can be prescribed as a treatment for elevated total cholesterol and other types of lipid disorders, but it should only be used with medical supervision due to its potential for severe side effects.
The general recommended intakes for niacin are listed below:
Age 14 and up: 14 mg/d
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Whilst it is rational to take B2 as part of a B complex supplement, there is a difference in the various preparations of vitamin B complex. Vitamin B complex contains
B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B12, Folic acid and Biotin.
However, high strength vitamin B complex (such as B-50 complex) also contains Choline Bitartrate, Inositol, and PABA.
Yes, that's right
B-50 complex contains choline so avoid that preparation if you have trimethylaminuria!