Iodine will work synergistically with the artemesia and increase it's effectiveness significantly. It is like a combination of soap and nutrition for the liver. You cannot over dose on it, although you can have some strong detox symptoms if you've got a lot of flukes. So start low and increase until you reach your tolerance level, then push beyong. I took 120 drops three days in a row this week. Something deep in my lungs is breaking up, finally, and coming out.