I feel (and practice) that a 2 hour window before and after is good. If you do it too close to food, it could take the Miracle-Mineral-Supplement further into the GI track. This may also be good once in while. The point is for the Miracle-Mineral-Supplement to make it into the bloodstream. You don't want the Miracle-Mineral-Supplement to waste effort instead of doing its real job. The best way for it to make it into the bloodstream is from the lining of the stomach or upper GI track.