I read a few websites where the rule is to take supplements so many days on and then stop for the same amount of days. They say they have more success with helping the patients that way. So I've been taking Lugols 1 day on and 1 day off to see if it worked and it is actually working quite well. I started with 2 drops. Then tried 4 drops and 2 iodoral. It seems as long as I give my body the break to take care of business I don't seem to have the negative effects that I did when I first started taking Lugols daily without the breaks. I've only been doing it for a few weeks this way. But so far so good.