You might want to ask this question about nail fungus in the "ask curezone" support forum - you might get a better response. I certainly am not promoting accutane, because this is an alternative health forum, but it is the only substance that consistently will clear up acne. Acne can be caused by numerous things but accutane will clear up Acne in 95% of sufferers. The only thing is that it does nothing to get to the root cause. In many cases the Acne will return after you go off of it. I have done several courses of it and it cleared it up each time, one time for several years. It definitely dries out your skin.