Not sure about why you are not responding to the laxatives. I know that medical laxatives always stop working after a while and doctors recommend against them because of that on a long term basis. I have had problems with that too but have chronic constipation due to parasites. I often respond if I take bulk herbs, laxatives and parasite herbs in a combo and do liver cleanse and don´t eat pain killers or other drugs, although I have to still take pain killers unfortunately. I have heard people complaining that cascara sagrada which is a strong laxative stops working on other forums but I still like that herb though. Also I don´t use it every day in case it will stop working. For me it´s good to use parasite herbs because the worms are so large that they are blocking my intestines (small intestines). They start moving to get away from the herbs and the food can go through more easily. If I take bowel herbs or psyllium it bulks the food up and with cascara sagrada it helps to spasm the bowel somehow so it starts working. I can´t rely on laxatives alone though. If it´s really bad I do an enema but haven´t done it in a long time. I use to do it a lot before, especially after 4 months on Antibiotics . If you go to the other forum constipation forum they have some good ideas as well.