Major DNA breakthrough...simple yet ... 
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Ok, I've been coming to terms that EC probably is a more simple condition than we have thought. So, I've been going back to simpler theories. I checked my DNA again and found something I overlooked because it didn't seem like a big deal. However, it's listed as a rare DNA defect. Genetically, my body produces less vitamin B12. I never worried about B12 because my blood levels have always shown a high level of B12 although I don't take vitamin B supplements. But my blood tests also show a high level of folate although my DNA shows a defect in my body's ability to produce folate. What I'm trying to say is vitamins your body naturally has a hard time producing/absorbing may show excess in your blood since your body isn't absorbing it. I hate the smell of regular B12 vitamins, and my body probably doesn't absorb them well. Hence, I tried coenzyme B12 for better absorption.
Whatever the reason your lips peel, open/raw skin breeds yeast/bacteria. Drooling from mouth breathing and dry mouth is ideal environment for yeast. My lips never felt better after taking these coenzyme B12 vitamins (that don't smell like regular B12 vitamins).
I hope this helps some people here.
- Re: Major DNA breakthrough...simple ... longterm
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This is a reply to # 2,430,066Besides the B12 genetic defect, I have a few of the following factors.
"The following factors may put you at a higher risk of not getting enough vitamin B12 from diet alone:
- vegetarian or vegan diet
- over 50 years old
- gastrointestinal disorders, including - - - Crohn’s disease and celiac disease
- surgery on the digestive tract, such as weight loss surgery or bowel resection
- metformin and acid-reflux medications because it decreases calcium absorption and lowers gastric acidity
- specific genetic mutations, such as --MTHFR, MTRR, and CBS
- regular consumption of alcoholic beverages
- reduced calcium intake may cause low B12 levels due to the action of intrinsic factor, which is dependent on calcium channels"
Bad genes can turn on or off. You might have been born with this bad gene, but it didn't turn on until later in life. There are several different factors that can make a bad gene turn on or off.
If you have taken or you are taking regular B12 supplements, but you haven't noticed improvement, switch to the coenzyme type to see if it makes a difference. Also, make sure it's a trusted or not fake vitamin full of fillers. I remember wondering why my lips seemed better when I drank lots of regular milk...maybe it was the calcium. But maybe the bad gene wasn't turned on, yet.
- Re: Major DNA breakthrough...simple ... longterm
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MoreThis is a reply to # 2,430,096I want to add that I tried regular B12 vitamins in the past for a short period of time due to side effects. I probably had side effects because I wasn't absorbing it well, and it didn't improve my lips. I wasn't taking a regular B12 vitamin whenever I had my B12 blood test. I also didn't think it was important for me to take B12 because my blood tests showed a high level of it.
This link might be helpful. The vitamin B12 supplements that I have used in the past contained Cyanocobalamin (synthetic). The one I use now contains Methylcobalamin (natural) and dibencozide, which is also known as adenosylcobalamin.
https://www.healthline.com/nutrition/methylcobalamin-vs-cyanocobalamin
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This is a reply to # 2,430,109Here's vitamin deficiences that can cheilitis:
B2, B9, B12, scurvy (vitamin C), iron deficiency, or zinc deficiency
Sice there's 3 vitamin Bs listed, a vitamin B complex could cover them all if you're not sure if you have one or the other.
UPDATE: I switched from a coenzyme B Complex vitamin to a coenzyme B12 (without the other B vitamins because the Niacin or B3 was causing a fast heart rate. I don't find the new vitamin to help as much. Could it just be the lower quality brand or could I be lacking morw than one B vitamin? So, I'm going to buy another coenzyme B Complex vitamin with half the amount of Niacin (50 mg instead of 100mg).
Yes, I just tried another brand of coenzyme B Complex vitamin. I works just as well without the fast heart rate. Therefore, I recommend the B Complex over B12 alone. However, the B12 vitamin was a dissolve in your mouth type of vitamin so that could be the problem.
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- Re: Major DNA breakthrough...simple ... longterm
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This is a reply to # 2,430,066Read this article. I have both the MTHFR and COMT genetic defects which might be related to my B12 absorption genetic defect. It's contradictory how you're not supposed to take a particular vitamin for MTHFR if you have COMT and vice versa. Maybe I could message the author of this article. This Niacin in the B Complex is killing me making me feel so wired. Plus, I can't take the same vitamin for both MTHFR and COMT genetic defects.
https://lauraschoenfeldrd.com/is-your-b-complex-vitamin-doing-more-harm-than-good/
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MoreThis is a reply to # 2,430,215I guess my body got used to the Niacin since my heart isn't racing as much, but I'd prefer no Niacin in the B complex. Even if it's contradictory that I can't take the same supplement with MTHFR and COMT genetic defects, it's working for me anyway. In the beginning, I bought several bottles of coenzyme B complex brands to see which one worked best. Each brand is formulated a little different. I've been sticking with one that has at least 500 mcg of B12 since that's what worked from the start. I also need B6 (and possibly riboflavin B2). I discovered the B vitamin absorption problem was the sure cause of my EC because my lips are totally normal now. Lack of B6 can also make you feel anxious.
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This is a reply to # 2,430,293Are you taking INNATE? Can you specify what brand of B-complex you are ingesting?- Re: Major DNA breakthrough...simple ... longterm
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This is a reply to # 2,430,297No, I'm not taking the Innate brand. IT NEEDS TO BE THE METHYLATED FORM. It's between Emerald Coenzymated B-Healthy or Igennus Super B Complex. I'm trying to figure out which one works best...perhaps Igennus Super B Complex due to less Niacin and less ingredients. Keep in mind that while you have a deficiency you need to rely on the B vitamin on a daily basis until your level is normal. However, my level will likley never be normal without the help of B vitamin due to my vitamin B absorption problems. What I'm saying is I notice my lips losing it again if I don't take the B vitamin every morning.
Read the directions. One brand instructs to take two supplements once a day. Another brand instructs to take one supplement twice a day.
Also, the drug ACCUTANE causes B12 deficiency as well as intestinal damage/absorption problems.- Re: Major DNA breakthrough...simple ... longterm
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This is a reply to # 2,430,314The original DNA defect I found was with Tcn1 gene, which binds with femtomolar affinity and protects it from the acidic environment of the stomach. This is a strong red flag in my DNA with a rare frequency rate of 0%. Hence, there's likely an issue with B12 not surviving the acidity of my stomach. Maybe B12 shots would help with this issue. However, B12 shots might not work for the other MTHFR/COMT gene defect because my body has trouble converting regular B12 or absorbing it. That's where the coenzyme B Complex supplements come in handy. It's puzzling how these supplements get absorbed if my stomach acid destroys B12 (without the Tcn1 protection other people have). Maybe because it's a different form of B12? At this point, I don't yet know if my B12 level will ever reach a normal level, but I'd still need to keep taking the B supplements regardless.
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This is a reply to # 2,430,351MAJOR CORRECTION! I should delete this whole thread and rewrite it into one post because I kept adding information as I found it. The site I used to find my MTHFR and COMT gene mutations doesn't break down the information like it used to. From memory, I remembered MTHFR and COMT mutations showing up. However, I have the COMT double allele mutations while a relative has the MTHFR double allele mutations. I only have one allele mutation instead of double allele mutations for the MTHFR mutation. If you have the MTHR double allele mutations, the Methylcobalamin I've been taking is recommended as well as B6 and other vitamins included in the B Complex package. But if you have the COMT mutations, Hydroxocobalamin and Adenosylcobalamin is recommended. I haven't taken this yet, and it's not the regular Cyanocobalamin B12. So, I'm going to try the Hydroxocobalamin and Adenosylcobalamin. I wanted to clarify that I don't have both MTHF and COMT double allele mutations. In my opinion, the COMT mutations might affect the lips more because the relative with the MTHFR doesn't have my lip peeling problem.
Since the MTHFR gene has enzyme that makes vitamin B-12 (methylcobalamin) active, maybe it was helpful to the one allele mutation of MTHFR so I could absorb some of it. Or maybe Methylcobalamin is more resistant to stomach acid than the regular Cyanocobalamin (considering my other DNA gene mutation of Tcn1= destruction of B12 by my stomach acid). I'll try the Hydroxocobalamin and Adenosylcobalamin to see if it makes my body feel more relaxed.
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This is a reply to # 2,430,425Another Update: While the Methylcobalamin increases my heart rate too much (it might just be due to Niacin in the B Complex), the Hydroxocobalamin/Adenosylcobalamin increases my blood pressure too much (the dosage was much hugher at 2000 mcg istead of 500 mcg in the Methylcobalamin. The side effects of Hydroxocobalamin/Adenosylcobalamin can either be high or low blood pressure. It might be due to either my MTHFR or COMT gene mutations, too. I might try a Methylcobalamin B12 cream on my lips instead of taking the supplements. I'm not quite sure how to deal with this peculiar issue.
https://www.drweil.com/health-wellness/body-mind-spirit/hair-skin-nails/b12-cream-for-eczema/
Try to avoid creams with avocado oil and citric acid (it's hard to find, but I read these ingredients in B12 creams aren't helpful for your lips).
I don't like the Niacin I see listed in the Methylcobalamin B12 cream I saw so I might try a Methyl-B-12-Spray on my lips that ca also be ingested. The Methyl is important because it saves a step in converting B12, which seems to be a problem for me. Because the Methylcobalamin B12 supplement by itself without the other B Complex ingredients (like B6) wasn't effective, I don't want to ingest that supplement. It was the supplements that you dissolve in your mouth, then ingest. I had trouble finding a Methylcobalamin B12 supplement that wasn't in liquid form or meant to totally ingest without dissolving in your mouth. Applying it directly to the lips may be key if ingestion is a problem. However, the Methyl B12 skin patch is another option.
Here's a Methyl B12 patch. It has Niacin, but only 10 mg instead of 50 mg. I don't know if this lesser amount can also increase my heart rate. Niacin in a multi-vitamin adds up with the Niacin in the B Complex supplement.
https://texastransdermals.com/mthfr-patch/
I tried both the Methylcobalamin and the Hydroxocobalamin/Adenosylcobalamin . The Methylcobalamin worked better on my lips. It may due to saving a step in converting B12 for absorption. I could probably stick with the Methylcobalamin supplements if I used one with 10mg of Niacin.
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This is a reply to # 2,430,066In the past I wrote about a vitamin A absorption issue I found after I took a specialty vitamin absorption blood test. blood test. The only vitamin I wasn't absorbing at all was vitamin A. I had no explanation why, but I figured it was related to celiac disease. New DNA results for vitamin A absorption shows that I have a gene mutation affecting my body's ability to absorb vitamin A from food. This is something in addition to my vitamin B12 issue. I can't explain why the blood test didn't show an absorption issue with vitamin B12, but the test measured it in blood cells or not absorption in gut.
Here's my vitamin A report to follow up.
"Vitamin A is important for immune function, healthy eyesight, red blood cell production and skin health.
Sources of Vitamin A include preformed Vitamin A (e.g. retinol, retinyl palmitate, retinyl acetate) in animal products and provitamin A carotenoids (e.g. β-carotene) in fruits and vegetables.
Provitamin A carotenoids (e.g. β-carotene) in fruit and vegetables must be converted into active forms of Vitamin A (e.g. retinol, retinal, retinoic acid) before they can be used by the body.
BCMO1 is an enzyme that converts provitamin A carotenoids into active forms of Vitamin A. The activity of this enzyme affects how well your body makes Vitamin A. This trait analyses several variants of your BCMO1 gene (including rs11645428 and rs6564851), which change the activity of the BCMO1 enzyme.
You carry gene variants associated with low BCMO1 enzyme activity. Your body is less effective at making Vitamin A from provitamin A carotenoids (e.g. β-carotene) in fruit and vegetables. Therefore, you have an increased requirement for Vitamin A. You are at a greater risk of Vitamin A deficiency if you exclusively rely upon plant-based sources of Vitamin A (i.e. provitamin A carotenoids in fruits and vegetables)."
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